SIFT-MS delivers high-throughput solutions that eliminate bottlenecks in development, production, and QA/QC environments.
The real-time data output of SIFT-MS significantly shortens time to data and increases sample throughput. Analytical bottlenecks in pharma and CDMO applications can be overcome, increasing capacity and operational efficiency in applications such as residual solvent analysis, nitrosamine characterization, ethylene oxide and impurity detection, and detergent and sterilization monitoring.
Pharma and CDMO applications and use cases
Small Polar Molecules
SIFT-MS simplifies detection of small polar species by analyzing them directly from gas or headspace to sub-ppbV concentrations, without requiring derivatization or preconcentration.Read More
Residual Solvent Analysis
SIFT-MS provides rapid characterization of compounds that are not easily monitored by other technologies.Read More
Drug Delivery Devices
SIFT-MS provides a very rapid and highly sensitive solution for the detection of residual monomers and other impurities in diverse drug delivery devices.Read More
SIFT-MS revolutionizes packaging testing across diverse materials with its ability to analyze a very wide range of compounds rapidly.Read More
Syft is your answer in the Pharmaceutical industry
Industry issueFor pharmaceutical companies investing in scale-up of their manufacturing processes, the associated scaling of residual solvent testing using the USP<467> procedure requires significant upscaling of analysis capacities. This involves increased investments in qualified personnel, lab space, validation procedures and maintenance as well as higher overall instrument acquisition and running costs.
Competitive benefitThe validated SIFT-MS procedure meets the acceptance criteria in USP<1467>, and with 17-fold higher sample throughput, addresses current scale-up issues for residual solvent testing in the pharmaceutical industry.
Industry impactSince SIFT-MS uses direct, chromatography-free analysis, practical issues for the front-end separation are eliminated, resulting in a robust and reliable analytical result that is easily obtained and requires less qualified personnel. Capacity increase can thus be reached with just a single automated SIFT-MS instrument.
Rapid Volatile Impurity Analysis in Pharmaceutical Products Using SIFT-MS
Rapid, Simplified Residual Solvent and Volatile Impurity Analysis Using SIFT-MS
Drying Endpoint Monitoring Using SIFT-MS For Enhanced Manufacturing Of Active Pharmaceutical Ingredients
Process analysis using SIFT-MS enables the drying process to be monitored past the drying end-point measurable using conventional weighing methods. This delivers greater efficiencies for production, and lowers risk of thermally damaging sensitive APIs.
Simple, Rapid Analysis Of Ethylene Oxide In A Polysorbate 80 Excipient Using SIFT-MS
Quantitative ethylene oxide analysis in Polysorbate 80 excipient is greatly simplified using SIFT-MS, with a time to first test result that is eight-fold faster than the current compendial method and a
daily sample throughput that is 9- to 14-fold higher.
Routine Analysis 1: Why Labs and CROs Should Adopt Direct MS
Routine Analysis 4: Direct MS Simplifies Analysis of Challenging Compounds
Syft Application Talks 5: Determination of the Supercritical Carbon Dioxide Extraction End-Point
Part 4: Biomedical and Pharma
Online Demonstration: Pharmaceutical Applications
Pharmaceutical Method Validation for SIFT-MS
Simple, Rapid Analysis Of N-Nitrosodimethylamine (NDMA) Impurity In Ranitidine Products Using SIFT-MS
Quantitative analysis of volatile nitrosamine impurities in drug products is greatly simplified using SIFT-MS and has a three-fold throughput advantage (excluding sample prep benefits) over chromatographic methods.
Simple, Rapid Analysis Of Formaldehyde Impurities In Gelucire Excipient Using SIFT-MS
SIFT-MS greatly simplifies formaldehyde detection and quantitation through direct, instantaneous, and sensitive (sub-ppbV) sample ionization, yielding sample throughputs of up to 250+ samples/day.
Rapid Residual Solvent Analysis Validation Of An Alternative Procedure For USP Method <467> Using SIFT-MS
This study demonstrates that SIFT-MS provides an alternative procedure to USP<467>. Because SIFT-MS is inherently a rapid test technique (all sample components are simultaneously analyzed in about one minute per sample), this validated procedure can be used in organizations that require high-throughput testing, providing 17-fold daily throughput increase over GC-FID.
Simple Rapid Analysis of NDMA in a Recalled Valsartan Product Using SIFT-MS
Quantitative analysis of NDMA impurities in drug products is greatly simplified using SIFT-MS and has a three-fold throughput advantage (excluding sample prep benefits) over chromatographic methods.
High-Throughput, Quantitative Analysis of Benzene in Personal Care Products using Headspace-SIFT-MS
SIFT-MS provides rapid, sensitive, and robust analysis of benzene and other contaminants in a wide array of commercial products. Integration with a headspace autosampler enables rapid screening of hundreds of samples per day.
Real-Time Monitoring of Bioreactor Production Processes Using SIFT-MS
The ability of SIFT-MS to monitor critical volatile organic compounds (VOCs) produced by a bioreactor in real-time at low parts-per-billion by volume (ppbV) concentrations is demonstrated. This application note presents the results of a pilot-scale feasibility study conducted over several weeks, demonstrating the utility of SIFT-MS for maximizing production outcomes.
A Consumer Safety Expert Shares His Experience with SIFT-MS
We asked David Light, CEO and Founder of Valisure, about his experience using SIFT-MS and how it impacted their dry shampoo safety study.
Feedback from a CDMO SIFT-MS User
Hear what Christopher Williams, Senior Manager of Analytical Development, Alcami Corporation, had to say about his experience using SIFT-MS.
Rapid Screening of Paperboard For Volatile Leachables Using Static Headspace-SIFT-MS
Automated SIFT-MS analysis rapidly screens paperboard packaging for a wide range of functional groups in a single analysis, assuring that the volatile emissions meet manufacturer specifications. This application note describes a Headspace-SIFT-MS method with throughput >10X faster than traditional GC/MS methods.
Rapid, Quantitative Analysis of Volatile Aldehyde Impurities In Paperboard Using Multiple Headspace Extraction
Quantitative determination of volatile aldehyde residues in paperboard is readily achieved using multiple headspace extraction-SIFT-MS analysis, with an eight-fold throughput increase over the equivalent conventional analysis.
Rapid Odor Screening of Paperboard Using Static Headspace-SIFT-MS
Automated SIFT-MS analysis coupled with multivariate statistical analysis provides rapid sensory screening of paperboard packaging, overcoming the low sample throughput of sensory panels. The ability to use HS-SIFT-MS to achieve throughput of 12 samples per hour is demonstrated.
Rapid, Simplified Residual Solvent and Volatile Impurity Analysis Using SIFT-MS
SIFT-MS provides real-time, selective, and economic analysis of challenging volatile compounds, such as residual solvents, formaldehyde, dimethylamine, and NDMA without requiring derivatization or other special handling.
High-Throughput Analysis of Volatile Impurities in Sustainable Packaging using SIFT-MS
Pharmaceutical and food products are susceptible to contamination from packaging, whether from polymeric materials, printing inks, or paperboard. SIFT-MS, a high-sensitivity direct-injection mass spectrometry technique, enables risks associated with sustainable packaging alternatives to be mitigated through economical, high-throughput automated analysis (typically a 4- to 15-fold increase over GC-MS).
High-Throughput Quantitative Analysis of Residual Monomer by Using MHE-SIFT-MS to Calibrate Single Headspace Injections
MHE-SIFT-MS provides rapid, matrix-independent, quantitative determination of volatile leachables in polymers and calibrates quantitative analysis based on single headspace injections. This approach enables over 200 samples per day to be analyzed, delivering rapid and economic analysis of volatile leachables such as residual monomers.
Syft Tracer: The Next Generation of Volatile Impurities Analysis for Enhanced Workflows
This app note introduces the next generation of SIFT-MS, Syft TracerTM, which launched at Pittcon 2023. It revolutionizes volatile impurities analysis workflows through unparalleled speed, performance stability, and reproducibility. Learn about how this innovation to real-time trace gas detection outpaces chromatography-based methods in the analysis of challenging analytes such as formaldehyde in a PEG excipient.
Head to Head Comparison of Class 2A And 2B Residual Solvents Analysis Using Sift-MS And GC-FID
This application note describes head-to-head comparison of GC-FID and SIFT-MS analyses of Class 2A and 2B residual solvents. The techniques perform similarly for linearity and repeatability, but SIFT-MS provides superior performance for accuracy and recovery. Furthermore, SIFT-MS provides greater than 11-fold increase in sample throughput and significantly reduces the time taken to report quantitative results (over six times faster for a full calibration set).
Recent developments and applications of selected ion flow tube mass spectrometry (SIFT‐MS)
SIFT‐MS is now recognized as the most versatile analytical technique for the identification and quantification of trace gases down to the parts‐per‐trillion by volume, pptv, range. This statement is supported by the wide reach of its applications, from real‐time analysis, obviating sample collection of very humid exhaled breath, to its adoption in industrial scenarios for air quality monitoring. This review touches on the recent extensions to the underpinning ion chemistry kinetics library and the alternative challenge of using nitrogen carrier gas instead of helium.
The Latest Innovation of Real-Time, High-Throughput Volatile Impurities Analysis by SIFT-MS
Join us for this webinar to learn about Syft Tracer, the latest advancement of real-time, trace gas analysis by SIFT-MS which launched at Pittcon 2023. Hear how the recent product innovations unlock analytical bottlenecks and enable faster decisions to be made in critical process steps.
Syft Tracer Brochure
Syft TracerTM is the latest advancement in real-time, direct injection mass spectrometry (MS) built to solve the most difficult analytical challenges faced within a variety of industries and applications. This advancement to SIFT-MS delivers trace-level detection sensitivity, unparalleled performance stability, superior selectivity, and highly reproducible, quantitative data. Syft Tracer is optimized for high-throughput environments where continuous operation is the standard. Never miss a product or environmental contamination event again.
Even Faster Quantitation Of Formaldehyde In Gelucire Excipient
This application note describes how the efficiency of a MHE workflow can be significantly improved for MHE-SIFT-MS due to the stability of the technique. Formaldehyde impurity is analyzed easily and quantitatively in Gelucire excipient with this improved approach. The time-to-result is reduced to 85 minutes for this system – six-fold faster than the conventional MHE-SIFT-MS approach. Quantitative analysis is achieved at the throughput of 220 samples/day.