SIFT-MS has featured in many clinical studies to date, due to the clear appeal of using non-invasive techniques, such as breath analysis, to screen for diseases.
The originators of the SIFT-MS technique, Patrik Španěl and David Smith, and their colleagues, have once again shown that SIFT-MS is a feasible technique for cancer screening. In this instance, in vitro studies were carried out, in which a number of C3-C7 saturated aldehydes released during the electrochemically induced peroxidation of a lung cancer cell line, were identified and then measured in real-time.
These results are a promising start to future investigations in this area. By utilizing the power of this real-time direct MS technique, further such in vitro studies can be carried out on both normal cells and other types of cancer cells. Even more promising is the potential for detection of these volatile biomarkers on the breath of patients with such conditions.
The full paper can be accessed here.
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Written by Diandree Padayachee, Applications Specialist