SIFT-MS provides unsurpassed selectivity compared to other direct MS techniques.

SIFT-MS uses ultra-soft, precisely controlled chemical ionization (CI) coupled with mass spectrometric detection to rapidly quantify VOCs and permanent gases to low part-per-trillion concentrations by volume (pptv).

Eight chemical ionization agents (reagent ions) are applied in Syft instruments: H3O+, NO+, O2+, O, O2, OH, NO2, and NO3. These eight reagent ions react with analyte VOCs and inorganic gases in very well controlled ion-molecule reactions, but they do not react with the major components of air (N2, O2, and Ar).

This enables SIFT-MS to analyze air at trace and ultra-trace levels without preconcentration.

Rapid switching of eight reagent ions provides unsurpassed selectivity compared to other direct MS techniques.


SIFT-MS Analysis Methodology

  • Instantaneous, quantitative analysis of air and headspace with very high sensitivity and selectivity
  • Simultaneous analysis of chemically diverse VOCs (e.g. aldehydes, amines and organosulfurs)
  • Direct analysis of high humidity samples
  • Simplicity of operation
  • Simple integration with existing infrastructure
  • Low maintenance and long-term stability

There are three fundamental components of the SIFT-MS technique:

  1. Reagent ion generation and selection. The eight SIFT-MS reagent ions are formed by microwave discharge through moist or dry air at low pressure. One reagent ion is selected at any particular time using the first quadrupole mass filter.
  2. Analyte ionization. The selected reagent ion is injected into the flow tube and excess energy is removed through collisions with the carrier gas. The sample is then introduced at a known flow rate and the reactive compounds it contains are ionized by the reagent ion to form well-characterized product ions.
  3. Analyte detection and quantitation. Product ions and unreacted reagent ions are sampled into a second quadrupole mass spectrometer. Utilizing Syft’s compound library, the software instantaneously calculates each analyte’s absolute concentration.

For more information on how SIFT-MS can help your business

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