Automated SIFT-MS can determine volatiles within the packaging / product headspace of pharmaceuticals or medical devices to deliver efficient, selective screening and product testing in real-time.

Vaughan Langford Syft Technologies Director - Applications & Marketing

Dr. Vaughan Langford

BSc(Hons), PhD

Principal Scientist / Consultant

Vaughan joined Syft in 2002 after completing his PhD in Physical Chemistry at the University of Canterbury (1997) and post-doctoral fellowships at the Universities of Geneva, Western Australia, and Canterbury.

As manager of Syft’s contract laboratory, Vaughan has worked extensively with customers to understand their analysis needs and develop market-tested SIFT-MS solutions.

Vaughan has experience across all SIFT-MS application areas, but has particular expertise in environmental and food industry applications. He is an expert in SIFT-MS application and method development.

In addition to the technical aspects of his role, Vaughan attends and presents on many of Syft’s webinars and attends various conferences on our behalf.

Volatile compounds are common impurities in pharmaceutical products and are often of concern due to their toxicity. They can also represent a health and comfort hazard in both the outdoor and indoor environment. However, analysis using conventional chromatographic methods is slow, due to both sample preparation and chromatography.

Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) is a new analytical tool for real-time, selective, and economical trace gas and headspace quantification of volatile compounds,  including chromatographically challenging ones such as formaldehyde, formic acid, and ammonia. But how do you approach analytical method validation for SIFT-MS so that the data can be used to support regulatory requirements? By applying a strategy in accordance with International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) Validation of Analytical Procedures: Text and Methodology Q2(R1) Guidelines (or “ICH Q2(R1)”) to direct analysis methods using SIFT-MS, successful validation is readily achieved. This is illustrated by utilizing formaldehyde analysis as a case study.

This webinar describes how SIFT-MS works, how it speeds up analysis, and how it has been validated successfully in accordance with ICH Q2(R1) Guidelines suitable for pharmaceutical applications, such as regulatory submissions where GMP compliance is essential.