Syft Application Talks
#5. Determination of the Supercritical CO2 Extraction End-Point
Georgia Sanxaridou, CMAC/University of Strathclyde, United Kingdom

Georgia Sanxaridou is in the final stages of completing her PhD at the University of Strathclyde, UK, in the Continuous Manufacturing and Crystallization (CMAC) Future Manufacturing Research Hub.

For the majority of pharmaceuticals, the final step in drug substance isolation relies on drying for removal of organic solvents used in the upstream chemistry to deliver a pure API fit for downstream formulation and drug product manufacture. Current approaches for release, rely heavily on sampling with off line analysis to establish the end point of drying. Using SIFT-MS, an online measurement system has been devised, which has enabled real-time, high-resolution analysis of the performance of various conventional and novel drying technologies with little requirement for analytical method development. Example results and benefits of this approach are discussed.

Don’t miss this Syft Application Talk, which was originally recorded at the 2019 UK User Meeting in Cambridge, UK, in July 2019! Georgia will also present at the 2020 online European user meeting this coming July.