Knowledge Base

Learn more about the power of trace gas analysis using SIFT-MS. Download our latest brochures, application notes and white papers or watch an application-focused video. Questions? Contact us!

Various exciting applications of SIFT-MS formaldehyde analysis will be presented, including candle flame analysis, material emissions and evaluation of materials that scavenge gaseous formaldehyde.

This webcast focuses on case studies that demonstrate simple analysis of chromatographically challenging compounds. Formaldehyde receives special attention, as it is important across a wide range of industries (from environmental to pharmaceutical testing).

This application note demonstrates that by applying a strategy in accordance with International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) Validation of Analytical Procedures: Text and Methodology Q2(R1) Guidelines (or “ICH Q2(R1)”) to direct analysis methods using SIFT-MS, successful validation is readily achieved – even for formaldehyde.

This application note describes how challenging formaldehyde residue analysis becomes routine by utilizing automated thermal desorption-selected ion flow tube mass spectrometry (TD-SIFT-MS).

This application note describes the application of MHE-SIFT-MS to detection of C1 -C10 aldehydes and other oxygenated volatile organic compounds (VOCs) in paperboard.

This webinar describes SIFT-MS applications in the pharmaceutical industry, including:

• Its use as an alternative procedure for USP <467> residual solvent analysis
• Rapid, quantitative analysis of leachable formaldehyde from polyoxymethylene polymer and PEG excipient
• High-throughput headspace screening for nitrosamine residues in drug products
• Fast turnaround, simplified analysis of ethylene oxide residues in detergents used for cleaning validation.

SIFT-MS quantifies volatile compounds that are chromatographically challenging such as formaldehyde, formic acid and ammonia.  Direct, real-time analysis using SIFT-MS provides new opportunities across multiple pharma applications, including:

• Simple formaldehyde analysis
• Packaging screening, including residual monomer analysis
• Residual solvent analysis
• Cleaning validation
• Production facility air quality monitoring
• Bioreactor monitoring

Direct analysis using selected ion flow tube mass spectrometry (SIFT-MS) enables real-time monitoring of formaldehyde to sub-part-per-billion concentrations. SIFT-MS simplifies and accelerates both sampling and analysis of formaldehyde, providing 25-fold throughput enhancements.

SIFT-MS represents a major breakthrough for the pharmaceutical industry due to its ability to comprehensively analyze diverse VOCs and inorganic gas impurities with very high sample throughput.  It quantifies VOCs directly in real-time to sub-part-per-billion (ppb) concentrations, so that product issues are detected earlier and resolved immediately, delivering economic benefits to all stakeholders.

This webinar describes continuous environmental monitoring applications and presents a variety of case studies, including:

• Fenceline monitoring
• Real-time stack gas analysis
• Odor characterization at the source
• Continuous odor monitoring

SIFT-MS provides rapid and comprehensive analysis of landfill gas, making it ideally suited to the complete range of environmental and industrial applications.

This webinar discusses chemical and sensory-like analysis of wastewater treatment by SIFT-MS.  After introducing sensory and instrumental analysis of odor, it covers a wastewater treatment plant (WWTP) case study in detail, critiquing both instrumental and sensory methods available to this market.